BDBM50371228 Crestor::ROSUVASTATIN CALCIUM::Rosuvastatin::US9006282, Rosuvastatin

SMILES CC(C)c1nc(nc(-c2ccc(F)cc2)c1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)N(C)S(C)(=O)=O

InChI Key InChIKey=BPRHUIZQVSMCRT-VEUZHWNKSA-M

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50371228   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Redx Pharma

US Patent
LigandPNGBDBM50371228(Crestor | ROSUVASTATIN CALCIUM | Rosuvastatin | US...)
Affinity DataIC50:  4nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Redx Pharma

US Patent
LigandPNGBDBM50371228(Crestor | ROSUVASTATIN CALCIUM | Rosuvastatin | US...)
Affinity DataIC50:  9.03E+3nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed